Journal: ACS Central Science
Article Title: Molecular Fluorophores for Deep-Tissue Bioimaging
doi: 10.1021/acscentsci.0c00544
Figure Lengend Snippet: Current polymethine cyanine dyes for NIR-II bioapplication. (a) Enhancing bioavailability of cyanine dyes with micelle protection. (b, c) Chemical structure of IR-26, IR-1061, and Flav7. Quantification of the heart rate of the anesthetized mouse by NIR-II dynamic imaging with Flav7 micelle administration. Reproduced with permission. Copyright 2017, Wiley-VCH. (d) Schematic diagram of molecule–protein complex. Reproduced with permission. Copyright 2019, Science Publishing Group. (e) Chemical structures of IR-783, IR12-N3, and ICG. (f) Fluorescence imaging of mouse brain vasculature with ICG administration using different long-pass filters. Reproduced with permission. Copyright 2018, National Academy of Sciences. (g) Chemical structures of monodisperse polymethine LZ dyes. (h) Chemical structure of FD-1080 and NIR-II imaging of brain vasculature with FD-1080 administration under 808 and 1064 nm excitation. Reproduced with permission. Copy-right 2018, Wiley-VCH. (i) Chemical structure of 5H5-1069 and NIR-II imaging of abdominal vessels under 1064 nm excitation. Reproduced with permission. Copyright 2019, American Chemical Society. (j) Schematic illustration of modified method for reported NIR-II dyes with functional groups. (k) NIR-II low-pH ratiometric sensor BTC1070 for noninvasive gastric pH quantification. Reproduced with permission. Copyright 2019, Springer Nature. (l) A FRET sensor composed of CX-1 (donor) and CX-3 (acceptor) for ONOO – detection in mouse liver. Reproduced with permission. Copyright 2019, Wiley-VCH. (m) Chemical structure of IR-140 and the absorption spectra of IR-140 monomer and J-aggregates in hollow mesoporous silica nanoparticles. Reproduced with permission. Copyright 2019, American Chemical Society. (n) J-aggregates of self-assembly between FD-1080 and DMPC and the spectra properties of FD-1080 monomer and J-aggregates. NIR-II imaging of brain and hindlimb vessels with J-aggregates administration. Reproduced with permission. Copyright 2019, American Chemical Society.
Article Snippet: The low scattering and superior sensing accuracy of NIR-II ratiometric signals allowed for noninvasive gastric pH quantification under 4 mm biotissue penetration ( Figure k).
Techniques: Imaging, Fluorescence, Modification, Functional Assay
